Response to glucose and lipid infusions in sepsis: a kinetic analysis
The kinetics and oxidation of glucose and free fatty acid (FFA) metabolism were assessed in control and Escherichia coli septicemic dogs by using primed, constant infusions of U-/sup 14/C-glucose and 1,2, /sup 13/C-palmitic acid. In the controls, the infusion of glucose suppressed endogenous glucose production completely, whereas, in the septic dogs, only a 30% suppression of glucose production occurred. The ability of the septic dogs to oxidize endogenous or exogenous glucose was decreased significantly. The basal rate of appearance of FFA was significantly higher in the septic dogs, but their ability to oxidize FFA was comparable to that of the control dogs; therefore, the basal rate of FFA oxidation was higher in the septic dogs. These studies indicate that septic dogs have a decreased capacity to oxidize glucose, but that they retain their ability to oxidize long-chain fatty acids. Because the rate of lipolysis was increased in sepsis, lipid was the predominate energy substrate in this septic model.
- Research Organization:
- Univ. of Texas Medical Branch, Galveston
- OSTI ID:
- 5179998
- Journal Information:
- Metab., Clin. Exp.; (United States), Journal Name: Metab., Clin. Exp.; (United States) Vol. 5; ISSN METAA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BACTERIA
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CARBON 13
CARBON 14 COMPOUNDS
CARBON ISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DOGS
ESCHERICHIA COLI
EVEN-ODD NUCLEI
GLUCAGON
GLUCOSE
HEXADECANOIC ACID
HEXOSES
HORMONES
INFUSION
INSULIN
INTAKE
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
METABOLISM
MICROORGANISMS
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDATION
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
REACTION KINETICS
SACCHARIDES
SEPTICEMIA
STABLE ISOTOPES
VERTEBRATES