Exploratory research on mutagenic activity of coal-related materials
The following samples were found to be mutagenic for strains TA1538, TA98 and TA100 Salmonella typhimurium: ETTM-10, ETTM-11, ETTM-15, ETTM-16, and ETTM-17. ETTM-13 was marginally mutagenic for TA1537. ETTM-14 was slightly mutagenic for TA1537, TA1538, and TA98. Mutagenicity by all samples was demonstrated only in the presence of hepatic enzyme extracts (S9) which provided metabolic activation. ETTM-11 was shown to be the most mutagenic sample assayed thus far; specific activity was 2.79 x 10/sup 4/ TA98 revertants/mg sample. Fractionation by serial extractions with increasingly polar organic solvents was done at least 2 x with ETTM-10, ETTM-11, ETTM-15, ETTM-16 and ETTM-17. For some samples highly mutagenic fractions were observed.
- Research Organization:
- Cincinnati Univ., OH (USA). Dept. of Environmental Health
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AS22-78ET00222
- OSTI ID:
- 5179078
- Report Number(s):
- DOE/ET/00222-4
- Country of Publication:
- United States
- Language:
- English
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016000 -- Coal
Lignite
& Peat-- Health & Safety
560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
COAL LIQUIDS
EXTRACTION
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEPARATION PROCESSES