The repair of DNA damage: recent developments and new insights

Journal Article · Thu Jan 01 04:00:00 EST 1981 · J. Supramol. Struct. Cell. Biochem.; (United States)

DOI:https://doi.org/10.1002/jsscb.1981.380160109· OSTI ID:5177909

Friedberg, E C; Bonura, T; Love, J D; McMillan, S; Radany, E H; Schultz, R A

This brief review presents the salient features of new developments in the enzymatic repair of base damage to DNA. DNA glycosylases and apurinic/apyrimidinic (AP) endonucleases are reviewed and evidence is presented that in at least two prokaryote systems incision of UV-irradiated DNA occurs by the sequential action of these two classes of enzymes. In contradistinction, the uvrA, uvrB, and uvrC gene products of E coli appear to function as a multi-protein complex that catalyzes hydrolysis of phosphodiester bonds in damaged DNA directly. The inducible rapid repair of O6-methylguanine in E coli is also reviewed.

• Research Organization: Department of Pathology, Stanford University, CA
• OSTI ID: 5177909
• Journal Information: J. Supramol. Struct. Cell. Biochem.; (United States), Journal Name: J. Supramol. Struct. Cell. Biochem.; (United States) Vol. 16:1; ISSN JSSBD
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
550400 -- Genetics
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
BACTERIA
BIOLOGICAL PATHWAYS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DNA
DNA-ASE
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
ESCHERICHIA COLI
ESTERASES
HYDROLASES
MICROORGANISMS
MOLECULAR STRUCTURE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHOSPHODIESTERASES
RADIATIONS
RECOVERY
REPAIR
ULTRAVIOLET RADIATION