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Modulation of immune function by UV radiation

Journal Article · · J. Invest. Dermatol.; (United States)
;
In addition to its carcinogenic activity, ultraviolet (UV) radiation is capable of modifying certain immunologic reactions. Immunologic alterations induced in mice by UV radiation include both local and distant effects. Local alterations result from a direct effect of UV radiation on an immune reaction that takes place at the site of irradiation. Distant alterations are those in which exposure of skin to UV radiation at one site modifies an immune reaction occurring at a distant, unexposed site. Based on recent studies, the authors propose that there may be two types of distant alterations. One is nonspecific, may be due to accumulation of leukocytes at the site of UV-induced inflammation, and is exemplified by the suppression of delayed hypersensitivity and local graft-versus-host (GVH) reactions. The second may result from DNA damage, may involve a soluble mediator, and is manifested by the systemic suppression of contact hypersensitivity and the formation of antigen-specific suppressor T lymphocytes. These immunologic effects of exposure to UV radiation may be important in the pathogenesis of skin cancer and other cutaneous diseases.
Research Organization:
Univ. of Texas M. D. Anderson Hospital and Tumor Institute, Houston
OSTI ID:
5176861
Journal Information:
J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States); ISSN JIDEA
Country of Publication:
United States
Language:
English

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Related Subjects

550901 -- Pathology-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
IMMUNE REACTIONS
IMMUNITY
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSITIVITY
SKIN DISEASES
SOMATIC CELLS
ULTRAVIOLET RADIATION
VERTEBRATES