New techniques for positron emission tomography in the study of human neurological disorders
The general goals of the physics and kinetic modeling projects are to: (1) improve the quantitative information extractable from PET images, and (2) develop, implement and optimize tracer kinetic models for new PET neurotransmitter/receptor ligands aided by computer simulations. Work towards improving PET quantification has included projects evaluating: (1) iterative reconstruction algorithms using supplemental boundary information, (2) automated registration of dynamic PET emission and transmission data using sinogram edge detection, and (3) automated registration of multiple subjects to a common coordinate system, including the use of non-linear warping methods. Simulation routines have been developed providing more accurate representation of data generated from neurotransmitter/receptor studies. Routines consider data generated from complex compartmental models, high or low specific activity administrations, non-specific binding, pre- or post-injection of cold or competing ligands, temporal resolution of the data, and radiolabeled metabolites. Computer simulations and human PET studies have been performed to optimize kinetic models for four new neurotransmitter/receptor ligands, ({sup 11}C)TRB (muscarinic), ({sup 11}C)flumazenil (benzodiazepine), ({sup 18}F)GBR12909, (dopamine), and ({sup 11}C)NMPB (muscarinic).
- Research Organization:
- Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-87ER60561
- OSTI ID:
- 5176116
- Report Number(s):
- DOE/ER/60561-6; ON: DE92015353
- Country of Publication:
- United States
- Language:
- English
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New techniques for positron emission tomography in the study of human neurological disorders: Progress report, 15 June 1992--31 October 1992
New techniques for positron emission tomography in the study of human neurological disorders: Progress report, 15 June 1992--31 October 1992
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
CARBON 11
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
COMPUTERIZED SIMULATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ION EXCHANGE MATERIALS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGANDS
LIGHT NUCLEI
MATERIALS
MINUTES LIVING RADIOISOTOPES
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM DISEASES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXYGEN 18
OXYGEN ISOTOPES
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SIGNAL-TO-NOISE RATIO
SIMULATION
STABLE ISOTOPES
SYMPATHOMIMETICS
SYNTHESIS
TOMOGRAPHY