New techniques for positron emission tomography in the study of human neurological disorders
The general goals of the physics and kinetic modeling projects are to: (1) improve the quantitative information extractable from PET images, and (2) develop, implement and optimize tracer kinetic models for new PET neurotransmitter/receptor ligands aided by computer simulations. Work towards improving PET quantification has included projects evaluating: (1) iterative reconstruction algorithms using supplemental boundary information, (2) automated registration of dynamic PET emission and transmission data using sinogram edge detection, and (3) automated registration of multiple subjects to a common coordinate system, including the use of non-linear warping methods. Simulation routines have been developed providing more accurate representation of data generated from neurotransmitter/receptor studies. Routines consider data generated from complex compartmental models, high or low specific activity administrations, non-specific binding, pre- or post-injection of cold or competing ligands, temporal resolution of the data, and radiolabeled metabolites. Computer simulations and human PET studies have been performed to optimize kinetic models for four new neurotransmitter/receptor ligands, [{sup 11}C]TRB (muscarinic), [{sup 11}C]flumazenil (benzodiazepine), [{sup 18}F]GBR12909, (dopamine), and [{sup 11}C]NMPB (muscarinic).
- Research Organization:
- Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-87ER60561
- OSTI ID:
- 10154585
- Report Number(s):
- DOE/ER/60561--6; ON: DE92015353
- Country of Publication:
- United States
- Language:
- English
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New techniques for positron emission tomography in the study of human neurological disorders: Progress report, 15 June 1992--31 October 1992
New techniques for positron emission tomography in the study of human neurological disorders: Progress report, 15 June 1992--31 October 1992
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62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
CARBON 11
COMPUTERIZED SIMULATION
DOPAMINE
FLUORINE 18
ION EXCHANGE MATERIALS
KINETICS
LABELLED COMPOUNDS
LIGANDS
NERVOUS SYSTEM DISEASES
NEUROREGULATORS
OXYGEN 18
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE PRODUCTION
SIGNAL-TO-NOISE RATIO
SYNTHESIS
UNSEALED RADIONUCLIDES IN DIAGNOSTICS