Effects of lifetime ingestion of /sup 90/Sr in beagle dogs

Journal Article · Sat May 01 04:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575702· OSTI ID:5173003

Book, S A; Spangler, W L; Swartz, L A

To investigate the effects of lifetime /sup 90/Sr ingestion, fifteen beagle dogs were fed the equivalent of 1.3, 4.0, and 12.0 ..mu..Ci /sup 90/Sr. Exposures prior to weaning were made by maternal administration of one of the same /sup 90/Sr levels, begining at 21 days of gestation. Median survival was 12.5 years for the 1.3 ..mu..Ci/day group, 6.5 years for the 4 ..mu..Ci/day group, and 5.2 years of the 12 ..mu..Ci/day group, compared to unirradiated control values of 14.5 to 15 years. The normal life span of more than half of the 1.3 ..mu..Ci/day group is remarkable, considering they ingested 5900 to 7500 ..mu..Ci /sup 90/Sr during their lifetimes. One of seven 1.3 ..mu..Ci/day dogs died of mycloproliferative syndrome (MPS), while one of four 4 ..mu..Ci/day and one of four 12 ..mu..Ci/day dogs died from MPS. In addition, another 12 ..mu..Ci/day dog died of osteosarcoma and two others in the same group showed skeletal changes related to /sup 90/Sr exposure. Other deaths were as could be expected in normal canine populations. Lifetime skeletal doses, determined by periodic whole-body counting, were 1990-3750, 1880-9230, and 6360-14,680 rad for the 1.3, 4, and 12 ..mu..Ci/day groups, respectively. Comparison of these values with those from the large /sup 90/Sr toxicity study at Davis in which /sup 90/Sr feeding ended at 18 months of age indicates similar average skeletal doses from the two types of feeding regimens. The similarity of the skeletal doses may relate to the inability of /sup 90/Sr to be incorporated to any great extent into a mature skeleton that no longer has the high calcium turnover associated with early life. As a result, deaths from lifetime /sup 90/Sr ingestion appeared no earlier than when /sup 90/Sr ingestion ended in early adulthood.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5173003
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 90:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY BURDEN
CALCIUM
CHRONIC EXPOSURE
DELAYED RADIATION EFFECTS
DISEASES
DOGS
DOSES
ELEMENTS
EVEN-EVEN NUCLEI
INGESTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METALS
NEOPLASMS
NUCLEI
ORGANS
OSTEOSARCOMAS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
SARCOMAS
SKELETAL DISEASES
SKELETON
STRONTIUM 90
STRONTIUM ISOTOPES
SURVIVAL TIME
VERTEBRATES
YEARS LIVING RADIOISOTOPES