Vanadyl sulfate has prolonged insulin-like effects in the streptozotocin-diabetic rat

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5172963

McNeill, J H; C, Cam M; Pederson, R A; Faun, J ^[1]

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1. Univ. of British Columbia, Vancouver (Canada)

The effects of vanadyl sulfate in vivo were examined after 3 (DT3), 10 (DT3), 10 (DT10) and 17 (DT17) days post onset of diabetes. Wistar rats were made diabetic with streptozotocin and age-matched controls were administered vanadyl sulfate trihydrate ad libitum in the drinking water. At the concentration given, euglycemia was achieved in 44% of total DT rats without any increase in plasma insulin. The response rate was 33% in DT3, 64% in DT10 and 38% in DT17, without apparent toxicity over 5 months. Plasma cholesterol and triglycerides in the DT rats did not differ from control and were significantly lower than untreated diabetics (D). Oral glucose tolerance test performed at 5 months of treatment showed an improved glucose tolerance in the DT groups without substantial insulin release. The response rate was observed to be greater at higher concentrations. Subsequent to sustained euglycemia for 10 weeks and withdrawal from treatment for 20 weeks, several animals from the various groups maintained a state of euglycemia with normal oral glucose tolerance. This is in accordance with previous results from the authors' lab. Thus, oral vanadyl sulfate increases tissue sensitivity to insulin in response to an oral glucose load and normalizes various aberrations in plasma parameters after a two-week long diabetic state, which appear to be maintained for a significant period after treatment is withdrawn.

• OSTI ID: 5172963
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIABETES MELLITUS
PATHOGENESIS
GLUCOSE
METABOLISM
VANADIUM
BIOLOGICAL EFFECTS
INSULIN
RATS
ALDEHYDES
ANIMALS
CARBOHYDRATES
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METALS
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VERTEBRATES
560300* - Chemicals Metabolism & Toxicology