Studies on the mechanisms involved in multistage carcinogenesis in mouse skin

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:5172341

Slaga, T J; Fischer, S M; Weeks, C E; Klein-Szanto, A J.P.; Reiners, J

This report summarizes some important data which relates to the multistage nature of skin carcinogenesis. Topical application of some chemical carcinogens will induce skin tumors on mice. In general, most chemical carcinogens have to be given repetitively in order to induce a large number of tumors (complete carcinogenesis). Alternatively, skin tumors can be induced by the sequential application of a single sub-threshold dose of a carcinogen (initiation phase) followed by the repetitive treatment with a noncarcinogenic promoter (promotion phase). This second procedure employing initiation and promotion is referred to as two-stage carcinogenesis. The report provides evidence that an important aspect of tumor initiation by polycyclic aromatic hydrocarbons (PAH) is their metabolism to an electrophilic inermediate(s) which covalently interacts with epidermal DNA; provides evidence for the multistage nature of skin tumor promotion; correlates promotion associated morphological and biochemical responses with specific stages of promotion; and compares data on complete and two-stage carcinogenesis in various stocks and strains of mice in order to determine if tumor initiation and/or promotion is responsible for their varying sensitivities to skin cancer induction.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5172341
• Report Number(s): CONF-810350-2; ON: DE82011438
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CARCINOGENESIS
CARCINOGENS
COMPARATIVE EVALUATIONS
HYDROCARBONS
MAMMALS
METABOLISM
MICE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGY
POLYCYCLIC AROMATIC HYDROCARBONS
PROMOTERS
REACTION INTERMEDIATES
RODENTS
SENSITIVITY
SKIN
TUMOR PROMOTERS
VERTEBRATES