Strain differences and solvent effects in mouse skin carcinogenesis experiments using carcinogens, tumor initiators, and promoters

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:6304419

Slaga, T J; Fischer, S M

Skin tumors can be effectively induced in mice by the repetitive application of a carcinogen. The relative order of sensitivity to complete carcinogenesis is SENCAR > CD-1 > C57BL/6 > ICR/Ha Swiss greater than or equal to C3H greater than or equal to BALB/c. Skin tumors in mice can also be induced by the sequential application of a subthreshold dose of a carcinogen (initiation phase) followed by repetitive treatment with a weak or noncarcinogenic tumor promoter (promotion phase). The relative order of sensitivity to initiation-promotion is SENCAR much greater than CD-1 > ICR/Ha Swiss > BALB/c greater than or equal to C3H greater than or equal to DBA/2. The initiation phase requires only a single application of a carcinogen and is essentially an irreversible step, while the promotion stage is initially reversible, later becoming irreversible. The relative sensitivities of the strains of mice to polycyclic aromatic hydrocarbons (PAH), phorbol esters, benzopyrene, and other tumor promoters is discussed. The effects of solvent and manner of administration of the carcinogen are also investigated. (ACR)

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6304419
• Report Number(s): CONF-8104202-1; ON: DE83010700
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BODY
CARCINOGENESIS
CARCINOGENS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
ESTERS
HYDROCARBONS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PHORBOL ESTERS
POLYCYCLIC AROMATIC HYDROCARBONS
PROMOTERS
RODENTS
SENSITIVITY
SKIN
SOLVENTS
TUMOR PROMOTERS
VERTEBRATES