Morphological changes in cerebellum of neonatal rats exposed to 2. 45 GHz microwaves
Journal Article
·
· Prog. Clin. Biol. Res.; (United States)
OSTI ID:5163891
One-day and six-day old Sprague-Dawley rats were exposed in the far field to 2.45 GHz (cw) microwaves at 10 mW/cm/sup 2/ for five consecutive days, 7 hours per day (SAR 2W/kg). Pups were euthenized one day after exposure and the cerebella processed for light and electron microscopy. Matching cerebellar sections and folia from irradiated and sham irradiated animals were examined. Light microscopic examination revealed the presence of small deeply-stained cells with hyperchromatic pyknotic nuclei within the external granular layer (EGL). The number of these pyknotic cells in the experimental animals was nearly twice that in the controls. The Nissl bodies in Purkinje cells were finely dispersed. In some experimental animals mononuclear cellular infiltration was demonstrated. Under the electron microscope the deeply-stained pyknotic small cells presented electron dense nuclei with clumped chromatin, extrusion or disintegration of the nucleus, ruptured nuclear membrane, and the vacuolization of the cytoplasm. Eventually these cells became phagocytosed by surrounding EGL cells. Most of the Purkinje cells of experimental animals showed small, disorderly arrays of rough endoplasmic reticulum (RER) instead of the typical orderly stacks of parallel arrays. These observations suggest that microwave radiation may interfere with early genesis of cerebellar microneurons and alter the metabolic status of Purkinje cells. However, this effect might be reversible.
- Research Organization:
- George Washington Univ. Medical Center, Washington, DC (USA)
- OSTI ID:
- 5163891
- Journal Information:
- Prog. Clin. Biol. Res.; (United States), Journal Name: Prog. Clin. Biol. Res.; (United States) Vol. 257; ISSN PCBRD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of 2. 45 GHz microwave radiation on the development of Japanese quail cerebellum
Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster: early effects upon the neonatal cerebellar cortex-Part I
Effect of nonionizing radiation on the Purkinje cells of the uvula in squirrel monkey cerebellum
Journal Article
·
Sun Jan 31 23:00:00 EST 1982
· Teratology; (United States)
·
OSTI ID:5424636
Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster: early effects upon the neonatal cerebellar cortex-Part I
Journal Article
·
Mon Nov 30 23:00:00 EST 1981
· Environ. Res.; (United States)
·
OSTI ID:5724801
Effect of nonionizing radiation on the Purkinje cells of the uvula in squirrel monkey cerebellum
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· Bioelectromagnetics (N.Y.); (United States)
·
OSTI ID:5509526
Related Subjects
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CYTOPLASM
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
ENDOPLASMIC RETICULUM
MAMMALS
MEMBRANES
MICROSCOPY
MICROWAVE RADIATION
MORPHOLOGICAL CHANGES
NEONATES
NERVOUS SYSTEM
ORGANOIDS
ORGANS
RADIATIONS
RATS
RODENTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CYTOPLASM
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
ENDOPLASMIC RETICULUM
MAMMALS
MEMBRANES
MICROSCOPY
MICROWAVE RADIATION
MORPHOLOGICAL CHANGES
NEONATES
NERVOUS SYSTEM
ORGANOIDS
ORGANS
RADIATIONS
RATS
RODENTS
VERTEBRATES