Synthesis and evaluation of new iodine-125 radiopharmaceuticals as potential tracers for malignant melanoma

Journal Article · Thu Aug 01 04:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5161374

Michelot, J M; Moreau, M F; Labarre, P G; Madelmont, J C; Veyre, A J; Papon, J M; Parry, D F; Bonafous, J F; Boire, J Y; Desplanches, G G ^[1]

---

1. INSERM U 71, B.P. 184, Clermont-Ferrand (France)

The synthesis, labeling, and biodistribution of four 125I radiopharmaceuticals designed to localize in melanoma were tested. Uptake in tumors was demonstrated by autoradiography of whole-body sections and quantitated by measurement of radioactivity of selected tissues and tumors using melanoma-bearing mice. N-(2-diethylaminoethyl)-4-iodobenzamide was selected for its highest melanoma uptake: 60 min after 4 injection of 6.5% and 4% ID/g, respectively for murine B16 and human melanotic melanoma. Tumor uptake showed the highest values of all analyzed tissues from 6 to 24 hr after injection. High uptake in melanotic tumor tissue with relatively low uptake in blood, muscle, brain, lung, and liver tissue resulted in high tumor/nontumor ratios (at 24 hr for B16, tumor/blood = 37, tumor/brain = 147, tumor/muscle = 95). This agent was compared with iodoamphetamine. Scintigraphic images of the tumor confirmed that external detection of melanoma is possible with this new radiopharmaceutical.

• OSTI ID: 5161374
• Journal Information: Journal of Nuclear Medicine; (United States), Journal Name: Journal of Nuclear Medicine; (United States) Vol. 32:8; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AMPHETAMINES
ANALEPTICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MELANOMAS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PERFORMANCE TESTING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TESTING
TISSUE DISTRIBUTION
VERTEBRATES