Immunolymphoscintigraphy

Journal Article · Sun Oct 01 04:00:00 EDT 1989 · Seminars in Nuclear Medicine; (USA)

DOI:https://doi.org/10.1016/S0001-2998(89)80024-8· OSTI ID:5158544

Keenan, A M ^[1]

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1. Hospital of the Univ. of Pennsylvania, Philadelphia (USA)

Immunolymphoscintigraphy (ILS) refers to lymphatic administration of radiolabeled antibodies for lymph node imaging. Macromolecules such as immunoglobulins are preferentially taken up by lymphatic vessels rather than venous capillaries following interstitial injection. They then travel to regional nodes by lymph flow where they can interact with tumor cells, lymphocytes, or macrophages residing within the node. A variety of radiolabeled antibodies and their fragments have been studied, both in animals and humans, to test their ability to selectively target cells in lymph nodes. Preliminary clinical trials in patients with lymphoma, melanoma, and breast cancer suggest that immunolymphoscintigraphy holds great potential for accurate staging of early malignant disease. The procedure is safe and simple to perform, and offers a noninvasive means to detect small deposits of tumor in regional lymph nodes. Furthermore, direct intralymphatic administration results in even more efficient delivery of immunospecific agents, raising the possibility of radiotherapy by this route. 45 references.

• OSTI ID: 5158544
• Journal Information: Seminars in Nuclear Medicine; (USA), Journal Name: Seminars in Nuclear Medicine; (USA) Vol. 19:4; ISSN 0001-2998; ISSN SMNMA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
EFFICIENCY
GLOBULINS
IMMUNOGLOBULINS
ISOTOPE APPLICATIONS
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MAN
METASTASES
MONOCLONAL ANTIBODIES
NEOPLASMS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
REVIEWS
SCINTISCANNING
TRACER TECHNIQUES
VERTEBRATES