Direct intralymphatic injection of radiolabeled sup 111 In-T101 in patients with cutaneous T-cell lymphoma

Journal Article · Mon Jan 14 23:00:00 EST 1991 · Cancer Research; (USA)

OSTI ID:5985172

Mulshine, J L; Carrasquillo, J A; Weinstein, J N; Keenan, A M; Reynolds, J C; Herdt, J; Bunn, P A; Sausville, E; Eddy, J; Cotelingam, J D ^[1]

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1. National Cancer Institute, Bethesda, MD (USA)

Direct intralymphatic administration of radiolabeled monoclonal antibody in targeting antigen-bearing lymphoma cells in regional lymph nodes of patients with cutaneous T-cell lymphoma was evaluated. Seven consecutive patients undergoing staging lymphangiography received intralymphatic infusions of {sup 111}In-T101 to evaluate lymph node involvement. This procedure was accomplished without significant complication. The {sup 111}In-T101 rapidly distributed throughout the regional lymphatic compartment and passed into the systemic circulation. Tumor-bearing sites in the inguinal-femoral lymph nodes retained from 0.42 to 4.8% of the injected dose of radiolabeled antibody. Three patients were upstaged to Stage IVA based on tumor involvement found after radiolymphoscintigraphy-directed biopsy of groin lymph nodes, selected because of intense radioactivity by gamma camera imaging. Compared with previously reported s.c. antibody administration, there was a marked reduction in the radioactive exposure of normal tissues at the injection sites in the lower extremities. Direct intralymphatic delivery of {sup 111}In-T101 appears to be a feasible, efficient method for delivering therapeutic doses of radiolabeled antibody.

• OSTI ID: 5985172
• Journal Information: Cancer Research; (USA), Journal Name: Cancer Research; (USA) Vol. 51:2; ISSN CNREA; ISSN 0008-5472
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
EFFICIENCY
ELECTRON CAPTURE RADIOISOTOPES
IMMUNE SYSTEM DISEASES
IMMUNOLOGY
IMMUNOTHERAPY
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
RADIATION DOSES
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURVIVAL CURVES
THERAPY