Interpretation of the dose and LET dependence of RBE values for lethal lesions in yeast cells

Journal Article · Wed Feb 01 04:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576283· OSTI ID:5147210

Frankenberg, D

Survival data on yeast cells proficient or deficient in the repair of DNA double-strand breaks (dsb) and data on the induction of dsb are used to interpret the dose dependence of the RBE value for lethal lesions after irradiation at high dose rate followed by 72-hr liquid holding providing optimum conditions for repair of potentially lethal lesions (RBE/sub DP/, DP = delayed plating). The radiations applied are conventional (150 kV), soft (50 kV), and ultrasoft (4 kV) X rays, 30-MeV electrons (or /sup 60/Co ..gamma.. rays), and 3.5-MeV ..cap alpha.. particles. Analysis shows that the dose dependence of the RBE/sub DP/ value can be explained by the combination of two dose-independent RBE values, one for the single-particle traversal effect (RBE/sub spt/) and the other for the accumulation of dsb (RBE/sub dsb/) due to the traversal of more than one particle through the cell nucleus. Furthermore, it is shown that the LET dependence of RBE/sub spt/ values describing the linear component of the lethal lesions must be considered separately for ''electron'' and ''particle'' radiations.

• Research Organization: Abteilung fuer Biophysikalische Strahlenforschung, Frankfurt, West Germany
• OSTI ID: 5147210
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 97:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA PARTICLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHARGED PARTICLES
COBALT 60
COBALT ISOTOPES
DATA
DNA
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
ENERGY TRANSFER
EXPERIMENTAL DATA
FERMIONS
FUNGI
GAMMA RADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEPTONS
LET
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEIC ACIDS
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
STRAND BREAKS
SURVIVAL CURVES
X RADIATION
YEARS LIVING RADIOISOTOPES
YEASTS