Appearance of infused zinc ( sup 70 Zn) and oral zinc ( sup 68 Zn) in breast milk

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5146520

Moser-Veillon, P B; Patterson, K Y; Mangels, A R; Wallace, G F; Veillon, C ^[1]

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1. Univ. of Maryland, College Park (United States) Dept. of Agriculture, Beltsville, MD (United States) Perkin-Elmer Corp., Rockville, MD (United States)

The purpose of this study was to monitor the appearance of a simultaneous intravenous (IV) dose and oral dose of stable isotopes, {sup 70}Zn and {sup 68}Zn, respectively, in breast milk. Three lactating subjects, 2-3 months postpartum were fed a controlled diet which contained an average of 7.8 mg Zn/day. Subjects collected milk samples at the beginning of each feeding for a 24 hour period on the fifth day of the controlled diet. On day 7 of the controlled diet, a 160 ug IV dose of {sup 70}Zn as zinc chloride in saline was infused into each subject. The subjects also received 2 mg of {sup 68 }Zn as zinc chloride in 50 ml of orange juice. Following the stable isotope doses, subjects collected milk samples at the beginning of each feeding for 48 hours, weighing their infants before and after each feeding. The amount of natural Zn, {sup 70}Zn and {sup 68}Zn tracers in the milk was measured by isotope dilution mass spectrometry. The cumulative {sup 70}Zn excretion into breast milk over 48 hours was approximately 1% of the infused dose and the cumulative {sup 68}Zn excretion was smaller still. Thus, only a small fraction of a physiological IV or oral dose of zinc comes out in the milk. The small fraction of {sup 70}Zn and {sup 68}Zn appearing in the milk suggests that circulating zinc and dietary zinc are not rapidly or directly incorporated into breast milk in appreciable amounts.

• OSTI ID: 5146520
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ZINC
MEMBRANE TRANSPORT
INTRAVENOUS INJECTION
LACTATION
MASS SPECTROSCOPY
METABOLISM
MILK
ORAL ADMINISTRATION
TRACER TECHNIQUES
WOMEN
ZINC 68
ZINC 70
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
ELEMENTS
EVEN-EVEN NUCLEI
FEMALES
FOOD
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
MATERIALS
METALS
NUCLEI
PRIMATES
SPECTROSCOPY
STABLE ISOTOPES
VERTEBRATES
ZINC ISOTOPES
560300* - Chemicals Metabolism & Toxicology