Influence of selenium, age and dosage of 7,12-dimethylbenz(a)anthracene (DMBA) on the in vivo formation of DNA adducts in mammary tissue

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5146452

Liu, Jinzhou; Milner, J A ^[1]

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1. Pennsylvania State Univ., University Park (United States)

Diets formulated to contain selenium, as sodium selenite, 0.1 or 2 {mu}g/g were fed for 2 weeks prior to DMBA treatment. Food intake and weight gain were not influenced by Se intake. Anti- and syn-dihydrodiol epoxide adducts reached maximum binding by 24 h. Se supplementation inhibited by about 50% the appearance of both anti-and syn- DMBA-DNA adducts. Dietary selenium increased the rate of removal of the anti-dihydrodiol epoxide adduct bound to guanine, but delayed the removal of the other adducts. The occurrence of DMBA-DNA adducts correlated positively with the dosage of DMBA administered. Binding increased about 40% as the rat's age increased from 36 to 125 d. Se supplementation inhibited binding in 36, 54 and 125 d old rats. These data confirmed that dietary selenium is effective in inhibiting in vivo metabolism of DMBA.

• OSTI ID: 5146452
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
AGE DEPENDENCE
ANIMALS
AROMATICS
BENZANTHRACENE
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARCINOGENESIS
CONDENSED AROMATICS
DNA ADDUCTS
ELEMENTS
EXPERIMENTAL NEOPLASMS
GLANDS
HYDROCARBONS
IN VIVO
INHIBITION
MAMMALS
MAMMARY GLANDS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
SELENIUM
SEMIMETALS
SYNTHESIS
VERTEBRATES