Use of a jet mill for dispersing dry powder for inhalation studies

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668591395148· OSTI ID:5143075

Cheng, Y S; Marshall, T C; Henderson, R F; Newton, G J

Compressed air-powered jet mills are used in the chemical and food industries for grinding and classifying powders. The authors adapted one type of these fluid energy mills as a powder generator for inhalation experiments. The generating system included a jet mill and a screw feeder, the jet mill consisting of an elongated channel, a feeding jet to deliver the material into the channel, and two high-speed air jets. High speed air circulating in the channel created turbulence and centrifugal forces to disperse powder. The jet mill used can be operated from 25 to 100 psig at flow rates of 300 to 900 L/min. Two test materials-a solvent yellow dye and a dye mixture of solvent green and solvent yellow- were used. Both dyes were soft and sticky and could not be dispersed with several other powder generators tested at the concentrations required for toxicity studies. Aerosol concentrations ranging from 10 to 1500 mg/m/sup 3/ at a flow rate of 400 L/min were obtained by adjusting the feed rate to the jet mill. Stability of aerosol concentration during six-hour continuous generation was 15 to 20%. Comparisons of several generators for producing sticky organic powders are also discussed.

• Research Organization: Inhalation Toxicology Research Institute, Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5143075
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 46:8; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL GENERATORS
ANIMALS
DESIGN
DYES
FOOD PROCESSING
GRINDING MACHINES
INHALATION
INTAKE
MACHINE TOOLS
MAMMALS
POWDERS
PROCESSING
RODENTS
TOOLS
VERTEBRATES