DsRNA-based prevention of viral escape
Patent
·
OSTI ID:5141799
This patent describes a method of pretesting an animal or animal cells susceptible to human retroviral infection against viral-induced pathology secondary to antigenic drift, as evidenced by molecular rearrangement in the viral particle structure. It comprises: exposing the animal or cells isolated from the animal to a mismatched dsRNA which is a complex of a polyinosinate and a polycytidylate containing from 1 in 5 to 2 in 30 uracil or guanadine bases.
- Assignee:
- HEM Research Inc., Rockville, MD (USA)
- Patent Number(s):
- A; US 4963532
- Application Number:
- PPN: US 7-242341
- OSTI ID:
- 5141799
- Country of Publication:
- United States
- Language:
- English
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