Bioavailability of lead and chromium from encapsulated pigment materials

Journal Article · Fri Feb 01 04:00:00 EST 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01691948· OSTI ID:5138366

Clapp, T C; Kosson, D S ^[1]; Umbreit, T H; Meeker, R J; Gallo, M A ^[2]; Gray, D ^[3]

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1. Rutgers, The State Univ. of New Jersey, Piscataway (United States)
2. Univ. of Medicine and Dentistry of New Jersey, Piscataway (United States) Robert Wood Johnson Medical School, Piscataway, NJ (United States)
3. Cookson Pigments, Inc., Newark, NJ (United States)

Bioavailability is a major factor in determining toxicity of compounds taken into a human or animal. If an ingested compound is unable to cross the wall of the gut and enter into the body, then (except in very specialized cases) its capacity to cause systemic toxicity is small. Therefore, bioavailability is an important factor in determining the true exposure level for use in risk assessment models. The results of a study of relative oral bioavailability of lead and chromium from pigment materials in both natural and encapsulated forms are reported. The levels of lead and chromium were measured in the blood after 2 and 4 weeks of treatment and after a further 2 weeks of recovery. Blood levels were used as an index of metal uptake into the body. After the recovery period, both blood levels and tissue levels in the kidneys were measured.

• OSTI ID: 5138366
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States) Vol. 46:2; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTROSCOPY
BIOCHEMISTRY
BIOLOGICAL AVAILABILITY
BLOOD CHEMISTRY
BODY
CHEMICAL ANALYSIS
CHEMISTRY
CHROMIUM COMPOUNDS
KIDNEYS
LEAD COMPOUNDS
ORGANS
PIGMENTS
SPECTROSCOPY
TOXICITY
TRANSITION ELEMENT COMPOUNDS
UPTAKE