Evaluation of the 90-day inhalation toxicity of petroleum and oil shale JP-5 jet fuel. Technical report, July 1977-July 1983
Subchronic 90-day inhalation studies were conducted to compare the toxicity of Petroleum and Oil Shale derived JP-5 jet fuel. Beagle dogs, Fischer 344 rats, and C57BL/6 mice were continuously exposed to JP-5 at concentrations of 150 mg/m cum and 750 mg/cum 3. Unexposed control groups were also maintained. All dogs and a portion of each rodent group were sacrificed and examined at exposure termination. Remaining rodents were held for observation up to 21 months postexposure. The most significant exposure related effect occurred in male rats, where JP-5 produced nephropathy characterized by hyaline droplets, necrosis, and intratubular casts. Accentuated tubular degeneration and medullary mineralization were noted in exposed rats held for long-term postexposure observation. Female rats were free of significant JP-5 related renal damage. Consistent with the pathologic changes in male rats exposed to 750 mg/cu m 3 were increased kidney weight and increased serum creatinine and BUN levels. Reduced body weight gains also occurred in male rats exposed to JP-5. No pathologic lesions were observed in dogs exposed to JP-5. Hepatocellular vacuolization and fatty change occurred in mice exposed to JP-5 from either source and in rats exposed to Shale JP-5. The results of this study suggest that there are no substantial differences between Petroleum and Shale JP-5.
- Research Organization:
- California Univ., Dayton, OH (USA)
- OSTI ID:
- 5130226
- Report Number(s):
- AD-A-156815/3/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
04 OIL SHALES AND TAR SANDS
JET ENGINE FUELS
TOXICITY
PETROLEUM PRODUCTS
SHALE OIL
BLOOD SERUM
CREATININE
DAMAGE
DOGS
FATS
FEMALES
INHALATION
KIDNEYS
MALES
NECROSIS
PATHOLOGY
RATS
RODENTS
WEIGHT
ANIMALS
AZOLES
BODY
ENERGY SOURCES
FOSSIL FUELS
FUELS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
INTAKE
MAMMALS
MINERAL OILS
OILS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
VERTEBRATES
020900* - Petroleum- Environmental Aspects
020500 - Petroleum- Products & By-Products
041000 - Oil Shales & Tar Sands- Environmental Aspects
040600 - Oil Shales & Tar Sands- Products & By-Products