Stage II endometrial carcinoma treated with external-beam radiotherapy, intracavitary application of cesium, and surgery

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(89)90054-1· OSTI ID:5129984

Podczaski, E S; Kaminski, P; Manetta, A; Louk, D; Andrews, C; Larson, J; DeGeest, K; Mortel, R ^[1]

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1. Pennsylvania State Univ., Hershey (USA)

From September 1972 to September 1987, thirty-six patients with stage II carcinoma of the endometrium were treated with external-beam radiotherapy to the pelvis, a single intracavitary application of cesium-137, and extrafascial hysterectomy with adnexectomy. Patients were followed for a median of 54.4 months. Overall 2- and 5-year actuarial survival rates were 83 and 58%, respectively. Survival was analyzed in terms of the independent variables surgical stage, presence of a gross cervical lesion, and residual disease within the myometrium or cervix. Factors contributing to patients survival were analyzed by the log-rank method. The 12 patients with a gross cervical lesion had an adverse prognosis, as compared to those without such a lesion (P less than 0.05). Seven of the twelve patients (58%) with a cervical lesion at clinical staging demonstrated persistent or recurrent disease. The presence of extrauterine disease at surgery was a major prognostic factor in patient survival (P less than 0.01). All six patients with extrauterine disease expired 2.3 to 53.0 months after hysterectomy. Two patients with persistence of disease expired 2.3 and 7.5 months after hysterectomy. Eleven patients developed recurrent disease 2.1 to 56.5 months after hysterectomy. All presented with distant metastases. Four of the thirteen patients with persistent or recurrent disease had no residual tumor within the myometrium.

• OSTI ID: 5129984
• Journal Information: Gynecologic Oncology; (USA), Journal Name: Gynecologic Oncology; (USA) Vol. 35:2; ISSN 0090-8258; ISSN GYNOA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
CESIUM 137
CESIUM ISOTOPES
DISEASES
FEMALE GENITALS
FEMALES
ISOTOPES
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURGERY
SURVIVAL CURVES
THERAPY
UTERUS
YEARS LIVING RADIOISOTOPES