Ah receptor: relevance of mechanistic studies to human risk assessment
Journal Article
·
· Environ. Health Perspect.; (United States)
Studies of the toxic actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in numerous animal models and in human and animal cells in culture have established that the most characteristic pathologic lesions produced by this compound results from events initiated by the interaction of TCDD with a specific intracellular receptor protein, the Ah receptor. Although most research on the interaction of TCDD with the Ah receptor has focused on establishing involvement of this receptor complex in specific toxic responses, recent application of modern cell and molecular biology techniques is yielding new insights into the mechanism(s) of signal transduction. Elucidation of these mechanisms is essential for understanding the molecular basis of the cell and species specificity which is a hallmark of TCDD toxicity. This knowledge should provide the framework for development of a more toxicologically relevant risk assessment model.
- Research Organization:
- Chemical Industry Institute of Toxicology, Research Triangle Park, NC (USA)
- OSTI ID:
- 5129720
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 76; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Thesis/Dissertation
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:7164257
Equivalent molecular mass of cytosolic and nuclear forms of Ah receptor from Hepa-1 cells determined by photoaffinity labeling with 2,3,7,8-( sup 3 H)tetrachlorodibenzo-p-dioxin
Journal Article
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Mon Oct 29 23:00:00 EST 1990
· Biochemical and Biophysical Research Communications; (USA)
·
OSTI ID:6324722
2,3,7,8-tetrachlorodibenzo-p-dioxin pretreatment of female mice altered tissue distribution but not hepatic metabolism of a subsequent dose
Technical Report
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Sun Dec 31 23:00:00 EST 1989
·
OSTI ID:6521208
Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
BODY
CONFIGURATION INTERACTION
DIOXIN
DMSO
DOSE-RESPONSE RELATIONSHIPS
GROWTH FACTORS
HETEROCYCLIC COMPOUNDS
LYMPHATIC SYSTEM
MAMMALS
MAN
MEMBRANE PROTEINS
MESSENGER-RNA
MITOGENS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RECEPTORS
RISK ASSESSMENT
RNA
SKIN
SULFOXIDES
THYMUS
TOXICITY
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
BODY
CONFIGURATION INTERACTION
DIOXIN
DMSO
DOSE-RESPONSE RELATIONSHIPS
GROWTH FACTORS
HETEROCYCLIC COMPOUNDS
LYMPHATIC SYSTEM
MAMMALS
MAN
MEMBRANE PROTEINS
MESSENGER-RNA
MITOGENS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RECEPTORS
RISK ASSESSMENT
RNA
SKIN
SULFOXIDES
THYMUS
TOXICITY
VERTEBRATES