Effect of oxygen-radiosensitizer mixtures on the radiation response of Chinese hamster cells, line V. 79-753B, in vitro. I. Survival response
The effect of radiosensitizers on the survival of Chinese hamster cells irradiated in the presence of low concentrations of oxygen has been investigated. When the concentrations of oxygen and sensitizer were less than those which would separately produce an enhancement ratio (ER) of 1.9, sensitization was enhanced by the combinations. However, when the concentration of either agent was greater than that required to produce an ER of 1.9, there was no enhanced sensitization in the presence of the mixtures. The nitroxyl TMPN, which does not sensitize in our system, reduced the amount of sensitization produced by oxygen or misonidazole at concentrations that gave an ER of 1.9. When cells were irradiated in the presence of a low concentration of oxygen and 10/sup -4/ M of the biradical nitroxyl, Ro.03-6061, there was no change in the slope of the survival curve, but the shoulder removing property of the compound was abolished.
- Research Organization:
- Inst. of Cancer Research, Sutton, England
- OSTI ID:
- 5129532
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
COBALT 60
COBALT ISOTOPES
DISPERSIONS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
GAMMA RADIATION
HAMSTERS
IN VITRO
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MIXTURES
NONMETALS
NUCLEI
ODD-ODD NUCLEI
OXYGEN
OXYGEN ENHANCEMENT RATIO
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
VERTEBRATES
YEARS LIVING RADIOISOTOPES