Parabiotic demonstration of a humoral factor affecting megakaryocyte size in Sl/Sl/sup d/ mice (40263)

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-158-40263· OSTI ID:5126457

Ebbe, S ^[1]; Phalen, E; Howard, D

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1. Lawrence Berkeley Lab., CA

Parabiosis was done between Sl/Sl/sup d/ mice and their normal +/+ littermates and between pairs of +/+ mice. The purpose was to determine if Sl/Sl/sup d/ mice produced a substance that would stimulate megakaryocytopoiesis. It was found that +/+ mice attached to Sl/Sl/sup d/ mice showed macromegakaryocytosis suggesting that megakaryocytopoiesis was stimulated. Nonspecific findings in +/+ parabiotic pairs included a lesser degree of megakaryocytic macrocytosis. These findings did not appear to be due to growth of Sl/Sl/sup d/ stem cells in the +/+ parabionts. Radiation to Sl/Sl/sup d/ or +/+ bone marrow did not change the size of megakaryocytes. The results suggest that Sl/Sl/sup d/ mice produce a thrombopoietic substance even though they have a normal complement of circulating platelets.

• OSTI ID: 5126457
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 158; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550300 -- Cytology
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD FORMATION
BONE MARROW CELLS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
HORMONES
MAMMALS
MICE
MOSAICISM
PARABIOSIS
RODENTS
SIZE
SOMATIC CELLS
STEM CELLS
STIMULATION
THROMBOPOIESIS
VERTEBRATES