Abnormal lymphocyte response to ultraviolet radiation in multiple skin cancer

Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/6.6.843· OSTI ID:5124693

Munch-Petersen, B; Frentz, G; Squire, B; Wallevik, K; Horn, C C; Reymann, F; Faber, M ^[1]

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1. Finseninstitutet, Copenhagen (Denmark)

The lymphocyte response to ultraviolet radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The ultraviolet-induced DNA synthesis was determined as the increase in incorporation of (/sup 3/H)thymidine in irradiated cells compared with non-irradiated cells after incubation for 2 h. The ultraviolet tolerance was measured as the ultraviolet dose necessary for 50% reduction in phytohemagglutinin-stimulated lymphocyte proliferation. Patients with both squamous cell differentiated tumours and basal cell carcinomas had very high ultraviolet-induced DNA synthesis values. The ultraviolet tolerance in patient lymphocytes was considerably lower than in control lymphocytes with the lowest values occurring in patients with clinical sun intolerance. These investigations may be of predictive value in skin carcinogenesis.

• OSTI ID: 5124693
• Journal Information: Carcinogenesis (N.Y.); (United States), Vol. 6:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
SKIN
NEOPLASMS
DNA REPLICATION
NEAR ULTRAVIOLET RADIATION
PATIENTS
THYMINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MATERIALS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
ULTRAVIOLET RADIATION
URACILS
560121* - Radiation Effects on Cells- External Source- (-1987)