Effect of imidazole and indomethacin on hemodynamics of the obstructed canine kidney

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Kidney Int.; (United States)

DOI:https://doi.org/10.1038/ki.1985.97· OSTI ID:5119081

Balint, P; Laszlo, K

In the anesthetized dog renal blood flow (RBF) and its intrarenal distribution were investigated by the radioactive microsphere technique 24 hr after bilateral (BUL) and unilateral (UUL) ureteral ligation. In the control series indomethacin (IM) led to a decrease in RBF with outward shifting of zonal perfusions; imidazole (IA) did not cause significant changes in renal hemodynamics. In the BUL series there was a sharp drop in RBF with a proportional decrease in outer (OC) and inner (IC) cortical perfusion; IM treatment resulted in a further decrease in overall and zonal perfusions. IA, a selective inhibitor of thromboxane synthetase, relieved IC vasoconstriction. In the ligated kidney of the UUL preparations decrease in RBF was due to OC vasoconstriction, while IC perfusion equalled controls. IM led to an overall vasoconstriction in all cortical layers; IA did not influence either total RBF or its distribution. It was concluded that BUL ''unmasked'' TXA2 production in the IC layers, while IM treatment, by inhibiting the production of PGE2, PGI2, and TXA2, resulted in an overall vasoconstriction both in controls and the BUL and UUL preparations.

• Research Organization: Semmelweis Univ. Medical School, Budapest, Hungary
• OSTI ID: 5119081
• Journal Information: Kidney Int.; (United States), Journal Name: Kidney Int.; (United States) Vol. 6; ISSN KDYIA
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIPYRETICS
AZOLES
BIOLOGICAL EFFECTS
BLOOD CIRCULATION
BLOOD FLOW
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DOGS
DRUGS
ENZYME INHIBITORS
ENZYMES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ISOTOPES
KIDNEYS
LIGASES
MAMMALS
MICROSPHERES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERFUSED ORGANS
RADIOISOTOPES
VASOCONSTRICTION
VASODILATION
VERTEBRATES