Short-term tests of genotoxicity for 1,1,1-trichloroethane

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:5116405

Turina, M P; Colacci, A; Grilli, S; Mazzullo, M; Prodi, G; Lattanzi, G

Covalent binding of /sup 14/C-1,1,1-trichloroethane to macromolecules from rat and mouse liver, kidney, lung and stomach was analyzed under the same experimental conditions previously utilized in studying 1,1-dichloroethane and 1,1,2-trichloroethane. Labeling of DNA, RNA and proteins was very low both in in vivo interaction and in in vitro microsome-mediated binding. Interaction proceeded through the involvement of the P-450-dependent mixed function oxidase system from liver microsomes and, to a lesser extent, from lung microsomes. Covalent Binding Index of 1,1,1-trichloroethane in liver DNA was typical of very weak initiators. However, overall evaluation of the short-term assays available for 1,1,1-trichloroethane leads to limited evidence of genotoxicity. On the other hand, the evidence of 1,1,1-trichloroethane carcinogenicity in animals is still inadequate.

• Research Organization: Universita di Bologna, Italy
• OSTI ID: 5116405
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 3; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARBON 14 COMPOUNDS
CELL CONSTITUENTS
CHEMICAL BONDS
CHLORINATED ALIPHATIC HYDROCARBONS
DIGESTIVE SYSTEM
DNA
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MICE
MICROSOMES
MIXED-FUNCTION OXIDASES
NUCLEIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PROTEINS
RATS
RESPIRATORY SYSTEM
RNA
RODENTS
SOLVENTS
STOMACH
TOXICITY
TRACER TECHNIQUES
VERTEBRATES