Bone marrow replacement in the treatment of hemolytic disease in mice
Journal Article
·
· Experimental Hematology; (USA)
OSTI ID:5100132
- Jackson Lab., Bar Harbor, ME (USA)
Bone marrow replacement therapy following whole-body x- or gamma-irradiation has until now proven to be of limited value in the treatment of individuals with hemolytic disease. The large doses of radiation required for destruction of defective erythropoietic tissues coupled with their resultant high mortality appears to limit its usefulness. Techniques have been developed by the authors to limit the extent of exposure and to improve survival following irradiation. These techniques include shielding of all parts of the body except the hind limbs, prophylactic use of antibiotics, and preparatory blood transfusion to suppress the development of indigenous defective erythrocytes. Using these combined techniques we were able to establish high rates of survival, successful engraftment, and long-term clinical improvement in mice with several hemolytic disorders emanating from hereditary defects in spectrin production and incorporation. Evidence is presented indicating that complete bone marrow replacement occurs even in nonirradiated portions of the erythron and that only donor type red blood cells appear in the circulation.
- OSTI ID:
- 5100132
- Journal Information:
- Experimental Hematology; (USA), Journal Name: Experimental Hematology; (USA) Vol. 17:10; ISSN EXHMA; ISSN 0301-472X
- Country of Publication:
- United States
- Language:
- English
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THE EFFECT OF COLLOIDAL $sup 198$Au ON THE BONE MARROW AND ITS REPLACEMENT IN RABBITS
Journal Article
·
Mon Nov 30 23:00:00 EST 1987
· Exp. Hematol.; (United States)
·
OSTI ID:5719844
Postradiation migration of polypotent hemopoietic stem cells from shielded bone marrow of mice following hemorrhage and transfusion of syngenic erythrocytes
Conference
·
Fri Dec 31 23:00:00 EST 1976
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5339864
THE EFFECT OF COLLOIDAL $sup 198$Au ON THE BONE MARROW AND ITS REPLACEMENT IN RABBITS
Journal Article
·
Tue Mar 31 23:00:00 EST 1959
· Intern. J. Radiation Biol.
·
OSTI ID:4260452
Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CARBOXYLIC ACIDS
COLONY FORMATION
DISEASES
ELECTROMAGNETIC RADIATION
ELECTROPHORESIS
EXTERNAL IRRADIATION
GAMMA RADIATION
GENOTYPE
GLOBINS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CARBOXYLIC ACIDS
COLONY FORMATION
DISEASES
ELECTROMAGNETIC RADIATION
ELECTROPHORESIS
EXTERNAL IRRADIATION
GAMMA RADIATION
GENOTYPE
GLOBINS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION