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Radiation-induced emesis in monkeys

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575247· OSTI ID:5099603
;
To determine the emesis ED/sub 50/ for /sup 60/Co radiation, 15 male rhesus monkeys were exposed to whole-body radiation doses ranging from 350 to 550 rad midline tissue dose. An up-and-down sequence of exposures was used. Step size between doses was 50 rad, and dose rate was 20 rad/min. There had been no access to food for 1 to 2 h. The ED/sub 50/ +- SE was found to be 446 +- 27 rad. To determine the effect of motion on emesis ED/sub 50/, six more monkeys were exposed to /sup 60/Co radiation as above, except that the chair in which they were seated was oscillated forward and backward 5 to 15/sup 0/ (pitch axis) at a variable rate not exceeding 0.3 Hz. Radioemesis ED/sub 50/ +- SE with motion was 258 +- 19 rad, a value significantly lower (P < 0.01) than for stationary monkeys.
Research Organization:
USAF School of Aerospace Medicine, Brooks Air Force Base, TX
OSTI ID:
5099603
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:1; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXTERNAL IRRADIATION
FASTING
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MACACUS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONKEYS
MOTION
NAUSEA
NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
SYMPTOMS
VERTEBRATES
VOMITING
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES