Cardiac function in patients with prior myocarditis

Journal Article · Tue Jul 01 04:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:5099151

Das, S K; Brady, T J; Thrall, J H; Pitt, B

Gated cardiac blood-pool imaging under rest and exercise was used to assess left-ventricular functional reserve in six asymptomatic patients with prior myocarditis and six age matched control subjects. Coronary artery disease was excluded in three of the six patients by coronary arteriography. In the remaining three, coronary artery disease was thought unlikely on the basis of history and the presence, during exercise, of a normal ECG and normal Tl-201 myocardial image. Conventional indices of resting left-ventricular function - including cardiothoracic ratio, echocardiographic left-ventricular diameter, and percentage change in minor diameter - were normal in those with prior myocarditis. The mean resting left-ventricular ejection fraction was also normal by gated blood-pool imaging, and not significantly different from that for control patients: 0.58 +- 0.05 and 0.65 +- 0.02, respectively. Three patients with prior myocarditis had resting left-ventricular ejection fractions of less than 0.50. On exercise, the patients with prior myocarditis decreased their mean left-ventricular ejection fraction by an average of 8% compared with an increase of 15% in the control group (p < 0.01). This study suggests that asymptomatic patients with prior myocarditis have left-ventricular dysfunction that may not be clinically apparent, and suggests the need for further long-term follow-up.

• Research Organization: Univ. of Michigan School of Medicine, Ann Arbor
• OSTI ID: 5099151
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFLAMMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLED POOL TECHNIQUES
MATERIALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TRACER TECHNIQUES
USES
YEARS LIVING RADIOISOTOPES