Clinicopathologic study of persistently positive technetium-99m stannous pyrophosphate myocardial scintigrams and myocytolytic degeneration after myocardial infarction

Journal Article · Thu Dec 01 00:00:00 EST 1977 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.56.6.1016· OSTI ID:5090553

Buja, L M; Poliner, L R; Parkey, R W; Pulido, J I; Hutcheson, D; Platt, M R; Mills, L J; Bonte, F J; Willerson, J T

In a select series of 46 patients studied by serial myocardial scintigraphy, 19 (41%) retained persistent, usually low grade (2+) positive technetium-99m stannous pyrophosphate (/sup 99m/Tc-PYP) myocardial scintigrams for at least 3 months after acute myocardial infarction. The one major difference between patients with positive and negative postinfarct /sup 99m/Tc-PYP myocardial scintigrams was a more symptomatic postinfarct course in the former group, characterized by severe angina pectoris in 16 of 19 patients and by severe congestive heart failure with angina in three patients. In a separate clinicopathologic series of seven patients, persistently positive /sup 99m/Tc-PYP myocardial activity was associated with prominent myocytolytic degeneration involving muscle cells which had survived initial episodes of infarction in 5 patients (three with ventricular aneurysms) and with extensive myocardial fibrosis in one patient with recurrent angina pectoris. One patient with a negative postinfarct /sup 99m/Tc-PYP myocardial scintigram had transmural fibrosis without residual myocardium in a resected ventricular aneurysm. It is concluded that a persistently positive /sup 99m/Tc-PYP myocardial scintigram frequently correlates with progressive myocardial damage and muscle loss and that this scintigraphic finding may be an important prognostic indicator of a complicated and symptomatic postinfarct clinical course.

• Research Organization: Univ. of Texas Health Science Center, Dallas
• OSTI ID: 5090553
• Journal Information: Circulation; (United States), Vol. 56:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
PATHOLOGICAL CHANGES
MYOCARDIUM
SCINTISCANNING
TECHNETIUM 99
CARDIOVASCULAR DISEASES
DIAGNOSIS
MYOCARDIAL INFARCTION
PATIENTS
PYROPHOSPHATES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics