Clinicopathologic study of persistently positive technetium-99m stannous pyrophosphate myocardial scintigrams and myocytolytic degeneration after myocardial infarction

Journal Article · Thu Dec 01 04:00:00 EST 1977 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.56.6.1016· OSTI ID:5090553

Buja, L M; Poliner, L R; Parkey, R W; Pulido, J I; Hutcheson, D; Platt, M R; Mills, L J; Bonte, F J; Willerson, J T

In a select series of 46 patients studied by serial myocardial scintigraphy, 19 (41%) retained persistent, usually low grade (2+) positive technetium-99m stannous pyrophosphate (/sup 99m/Tc-PYP) myocardial scintigrams for at least 3 months after acute myocardial infarction. The one major difference between patients with positive and negative postinfarct /sup 99m/Tc-PYP myocardial scintigrams was a more symptomatic postinfarct course in the former group, characterized by severe angina pectoris in 16 of 19 patients and by severe congestive heart failure with angina in three patients. In a separate clinicopathologic series of seven patients, persistently positive /sup 99m/Tc-PYP myocardial activity was associated with prominent myocytolytic degeneration involving muscle cells which had survived initial episodes of infarction in 5 patients (three with ventricular aneurysms) and with extensive myocardial fibrosis in one patient with recurrent angina pectoris. One patient with a negative postinfarct /sup 99m/Tc-PYP myocardial scintigram had transmural fibrosis without residual myocardium in a resected ventricular aneurysm. It is concluded that a persistently positive /sup 99m/Tc-PYP myocardial scintigram frequently correlates with progressive myocardial damage and muscle loss and that this scintigraphic finding may be an important prognostic indicator of a complicated and symptomatic postinfarct clinical course.

• Research Organization: Univ. of Texas Health Science Center, Dallas
• OSTI ID: 5090553
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 56:6; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATIENTS
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES