Early radiation dose-response in lung: an ultrastructural study
A systematic fine-structural study of dog lungs was undertaken to ascertain the radiation dose response in the lungs of large animals. The capillary endothelium appeared to be the initial site of the post-irradiation pulmonary damage. This subpheural response included diffuse septal thickening, fibrosis, edema, and reduced alveolar lumina. The deep parenchymal response involved perivascular fibrosis, which was associated with perivascular hyperplasia of Type II pneumocytes, increased number and sizes of lamellar bodies, increased production and release of lamellar surfactant. No changes of alveolar luminar size were noted. The most significant changes were observed in those dose zones exposed to greater than 2400 rad, suggesting the possibility of an identifiable dose-response relationship. Early detection of radiation pneumonitis by electron microscopy is demonstrated, and qualitative and quantitative correlation of injury with both postirradiation time and dose is presented.
- Research Organization:
- Strong Memorial Hospital, Rochester, NY
- OSTI ID:
- 5089735
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 2:9/10; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ENDOTHELIUM
FIBROSIS
INJURIES
IONIZING RADIATIONS
IRRADIATION
LOCAL IRRADIATION
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
ORGANS
PATHOLOGICAL CHANGES
PNEUMONITIS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RESPIRATORY SYSTEM
TISSUES
ULTRASTRUCTURAL CHANGES
VERTEBRATES
X RADIATION