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CHANGES IN LUNG PARENCHYMA WITH PREOPERATIVE Co$sup 60$-IRRADIATION OF BRONCHIAL CARCINOMA

Journal Article · · Krebsforschung und Krebsbekaempfung (West Germany)
OSTI ID:4654078
Histologic studies were made of resected lung tissue of 24 patients subjected to radiotherapy. Radiation pneumonitis with incipient fibrosis was observed in 14 cases. In only five of these cases could the histologic findings be confirmed radiologically. The histologic changes included swelling of alveolar septa, interstitial edema, increase of connective tissue components, giant cell formation, exfoliation of alveolar cells, intra-alveolar edema, depositio of cellular debris in small bronchi with apparent injury to the ciliated epithelial and mucous cells, and swelling of the peribronchial and perivascular tissue and pleura. Only a sparse inflammatory cell infiltrate was noted. These responses could not be closely correlated with the radiation dose. The radiation reaction was most marked in the vicinity of old tuberculous lesions. No permanent impairment of pulmonary function would be expected from the observed histologic changes. (H.H.D.)
Research Organization:
Deutsche Akademie der Wissenschaften, Berlin
NSA Number:
NSA-17-033692
OSTI ID:
4654078
Journal Information:
Krebsforschung und Krebsbekaempfung (West Germany), Journal Name: Krebsforschung und Krebsbekaempfung (West Germany) Vol. Vol: 3; ISSN KRKRA
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

BIOLOGY AND MEDICINE
CANCER
COBALT 60
CYTOLOGY
DISEASES
INFECTIONS
LUNGS
MAN
PNEUMONITIS
RADIATION INJURIES
RADIOTHERAPY
SURGERY
TUBERCULOSIS