Inhalation carcinogenesis of high-fired /sup 238/PuO/sub 2/ in rats. [Rats]

Journal Article · Thu Sep 01 04:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574622· OSTI ID:5089644

Sanders, C L; Dagle, G E; Cannon, W C; Powers, G J; Meier, D M

Wistar rats were given a single, nose-only exposure to freshly prepared high-fired /sup 238/PuO/sub 2/ particles (activity median aerodynamic diameter of /sup 238/PuO/sub 2/, 1.8 +- 0.6 ..mu..m), and the rats were observed over their life span. A total of 344 rats were examined: 294 exposed to /sup 238/PuO/sub 2/ and 50 serving as unexposed controls. A significantly increased incidence of malignant tumors was found only in the lung. Most of the lung tumors were adenocarcinomas followed in abundance by squamous cell carcinomas. The incidences of lung tumors were 0 in unexposed controls, 0.8 percent at an initial alveolar deposition of 0.14 nCi /sup 238/Pu, 7.5 percent at 11 nCi, 60 percent at 220 nCi, and 19 percent at 890 nCi. High-fired /sup 238/PuO/sub 2/ appeared to be less effective in producing lung tumors in the Wistar rat than was /sup 239/PuO/sub 2/, due possibly to the smaller amount of lung tissue irradiated by /sup 238/PuO/sub 2/ particles than by /sup 239/PuO/sub 2/ particles.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 5089644
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

054000 -- Nuclear Fuels-- Health & Safety
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BODY
CARCINOGENESIS
CHALCOGENIDES
DEPOSITION
DISEASES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PLUTONIUM 238
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIOINDUCTION
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES