Inhalation carcinogenesis of high-fired /sup 244/CmO/sub 2/ in rats

Journal Article · Wed Nov 01 00:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574787· OSTI ID:6391202

Sanders, C L; Mahaffey, J A

Wistar rats were given a single inhalation exposure to high-fired /sup 244/CmO/sub 2/ particles and the rats examined over their life span. A total of 395 rats were used: 277 were exposed to /sup 244/Cm to alveolar deposition levels of 0.54, 4.4, 48, 450, and 1800 nCi, and 118 served as unexposed controls. The activity median aerodynamic diameter of the aerosol was 0.8 +- 0.3 ..mu..m (mean +-SD). Autoradiographs of lung showed a uniform distribution of mostly single alpha d tracks in the lung parenchyma. About three-fourths of alveolarly deposited /sup 244/Cm was cleared from the lung with a half-life of 0.5 days, one-fourth with a half-life of 12 days, and about 2% was retained with a half-life of about 1 year. Uptake of /sup 244/Cm by bone reached a maximum by 50 days after inhalation and there-after showed no change. Retention half-life of /sup 244/Cm in liver and thoracic lymph nodes was less than 2 weeks. Significant early mortality due to radiation pneumonitis was seen in the two highest exposure groups. The incidence of lung tumors (all but one of which were adenocarcinomas) was 0% for unexposed animals, 1.8% following deposition of 0.54 nCi, 1.7% following 4,4 nCi, 13% following 48 nCi, 32% following 450 nCi, and 0% following 1800 nCi of /sup 244/Cm. A significantly increased number of tumors in bone and lung were found at depositions of 48 and 450 nCi of /sup 244/Cm. On an average lung dose basis, the dose--response pattern for the induction of pulmonary adenocarcinoma from inhaled /sup 244/CmO/sub 2/ was similar to that observed for inhaled /sup 239/PuO/sub 2/ despite large differences in particle size, solubility, and alveolar clearance.

• Research Organization: Battele Pacific Northwest Labs., Richland WA
• OSTI ID: 6391202
• Journal Information: Radiat. Res.; (United States), Vol. 76:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
CARCINOMAS
RADIOINDUCTION
CURIUM 244
INHALATION
LUNG CLEARANCE
RETENTION
LIVER
DELAYED RADIATION EFFECTS
LUNGS
MAMMARY GLANDS
OSTEOSARCOMAS
PNEUMONITIS
SKELETON
CHRONIC IRRADIATION
CURIUM OXIDES
INTERNAL IRRADIATION
RATS
SINGLE INTAKE
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHALCOGENIDES
CHRONIC EXPOSURE
CLEARANCE
CURIUM COMPOUNDS
CURIUM ISOTOPES
DIGESTIVE SYSTEM
DISEASES
EVEN-EVEN NUCLEI
EXCRETION
GLANDS
HEAVY NUCLEI
INTAKE
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SARCOMAS
SKELETAL DISEASES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)