Accumulation of sup 125 I-factor XI in atheroma of rabbit with hereditary hyperlipidemia (WHHL-rabbit)
Journal Article
·
· Thrombosis Research; (USA)
- Kansai Medical Univ., Osaka (Japan)
We have studied the turnover and accumulation of rabbit factor XI (F.XI) in atherosclerotic lesion in Watanabe-hereditable hyperlipidemic rabbit (WHHL rabbit) to reveal the participation of blood coagulation in atherosclerotic lesion. Rabbit F.XI was iodinated and administered intravenously to WHHL rabbits and Japanese white rabbits. The turnover of {sup 125}I-rabbit F.XI was significantly faster in WHHL rabbits (T1/2 = 2.84 +/- 0.44 days) than in normal rabbits (T1/2 = 4.44 +/- 0.42 days). The thoracic aorta of WHHL rabbit was strongly labelled with {sup 125}I-rabbit F.XI, in sections obtained after 5 days by en-face autoradiography, whereas no radioactivity was detected in normal aorta. By an immunohistochemical study of WHHL rabbit aorta, we confirmed that many F.XI- and fibrin-related compounds existed in the atheroma, whereas albumin did not in these area. These results suggest that the activation of F.XI proceeds on the atherosclerotic lesions of WHHL rabbits.
- OSTI ID:
- 5081451
- Journal Information:
- Thrombosis Research; (USA), Journal Name: Thrombosis Research; (USA) Vol. 56:1; ISSN THBRA; ISSN 0049-3848
- Country of Publication:
- United States
- Language:
- English
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Conference
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Fri Feb 28 23:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5459454
Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AORTA
ARTERIES
ARTERIOSCLEROSIS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COAGULANTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROTEINS
RABBITS
RADIOISOTOPES
VASCULAR DISEASES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AORTA
ARTERIES
ARTERIOSCLEROSIS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COAGULANTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROTEINS
RABBITS
RADIOISOTOPES
VASCULAR DISEASES
VERTEBRATES