Study of fatty acids in atheroma induced in rabbits by an atherogenic diet with or without silicon I. V. treatment
Journal Article
·
· Life Sci.; (United States)
Fifty-two rabbits were submitted for two months to an atherogenic diet with or without addition of silicon in the form of an I.V. silicon organic compound and compared to a control group of 21 rabbits. Out of the 26 rabbits receiving cholesterol alone, 23 showed atheromatous lesions; out of the 26 rabbits receiving cholesterol + silicon, only 8 had lesions. Free fatty acids, total fatty acids and esters were studied in the plasma and in the aorta. During atheroma, saturated fatty acids decrease, in particular 18:0, unsaturated fatty acids increase, in particular 18:1, 18:2, 20:4; with added silicon the variations are less important: in free fatty acids in plasma, there is a decrease of 20:4; in cholesterol esters in plasma and aorta an increase of 18:0 and a decrease of 18:2. There is a negative correlation between atheromatous lesions and myristic and stearic acids, and a positive correlation between oleic, linoleic and arachidonic acids and atheroma. Arachidonic acid, involved in phenomena of lipid peroxidation, decreased in the silicon treated rabbits.
- Research Organization:
- Laboratoire de Medecine Experimentale, Paris (France)
- OSTI ID:
- 6936127
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 42:21; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Wed Dec 31 23:00:00 EST 1986
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OSTI ID:6859703
Related Subjects
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTERIOSCLEROSIS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHOLESTEROL
DIET
DISEASES
ELEMENTS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
RABBITS
SEMIMETALS
SILICON
STEROIDS
STEROLS
SYNTHESIS
VASCULAR DISEASES
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTERIOSCLEROSIS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHOLESTEROL
DIET
DISEASES
ELEMENTS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
RABBITS
SEMIMETALS
SILICON
STEROIDS
STEROLS
SYNTHESIS
VASCULAR DISEASES
VERTEBRATES