Registration and three-dimensional reconstruction of autoradiographic images by the disparity analysis method
- Univ. of Miami, FL (United States). Cerebral Vascular Disease Research Center
- Univ. of Miami, Coral Gables, FL (United States). Dept. of Electrical and Computer Engineering
Quantitative autoradiography is a powerful radio-isotopic-imaging method for neuroscientists to study local cerebral blood flow and glucose-metabolic rate at rest, in response to physiologic activation of the visual, auditory, somatosensory, and motor systems, and in pathologic conditions. Most autoradiographic studies analyze glucose utilization and blood flow in two-dimensional (2-D) coronal sections. With modern digital computer and image-processing techniques, a large number of closely spaced coronal sections can be stacked appropriately to form a three-dimensional (3-d) image. 3-D autoradiography allows investigators to observe cerebral sections and surfaces from any viewing angle. A fundamental problem in 3-D reconstruction is the alignment (registration) of the coronal sections. A new alignment method based on disparity analysis is presented which can overcome many of the difficulties encountered by previous methods. The disparity analysis method can deal with asymmetric, damaged, or tilted coronal sections under the same general framework, and it can be used to match coronal sections of different sizes and shapes. Experimental results on alignment and 3-D reconstruction are presented.
- OSTI ID:
- 5079195
- Journal Information:
- IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States), Vol. 12:4; ISSN 0278-0062
- Country of Publication:
- United States
- Language:
- English
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