Distribution of cerebral blood flow during halothane versus isoflurane anesthesia in rats

Journal Article · Thu Sep 01 00:00:00 EDT 1988 · Anesthesiology; (United States)

DOI:https://doi.org/10.1097/00000542-198809000-00008· OSTI ID:6736566

Hansen, T D; Warner, D S; Todd, M M; Vust, L J; Trawick, D C

The effects of halothane versus isoflurane on distribution of cerebral blood flow (CBF) were compared using 14C-iodoantipyrine autoradiography. Sprague-Dawley rats were exposed to 1 MAC of either halothane (n = 8) or isoflurane (n = 7) in 33% O2/balance nitrogen for 55 min prior to determination of CBF. Normoxia, normothermia, and normocapnia were maintained throughout the experiment and arterial pressures (MAP) were held within the range of 90-100 mmHg by infusion of blood. Coronal autoradiographic brain images were then digitized and optical density values converted to CBF with the use of 14C autoradiographic standards and arterial radioactivity data. Hemispheric, neocortical, subcortical, and selected local anatomical regions were defined on a cathode ray screen display by cursor outline. Mean CBF for each region was determined at each of eight standardized coronal brain sections, and area weighted average values for the whole brain were also calculated. Hemispheric CBF was identical in the two anesthetic groups: halothane = 150 +/- 16 ml.100 gm-1.min-1; isoflurane = 147 +/- 19 ml.100 gm-1.min-1. However, neocortical CBF was greater in halothane anesthetized animals (halothane = 185 +/- 16 ml.100 gm-1.min-1; isoflurane = 154 +/- 19 ml.100 gm-1.min-1, P = .004). The authors conclude that halothane and isoflurane exert regionally selective effects on CBF with halothane appearing to have a more pronounced effect on the neocortex. Previously reported discrepancies concerning the relative effects of these two agents on CBF may be due to inherent differences in the tissue regions measured by the different techniques.

• Research Organization: Univ. of Iowa Hospitals and Clinics, Iowa City (USA)
• OSTI ID: 6736566
• Journal Information: Anesthesiology; (United States), Vol. 69:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANESTHESIA
BIOLOGICAL EFFECTS
BRAIN
BLOOD FLOW
ANTIPYRINE
AUTORADIOGRAPHY
BLOOD PRESSURE
BODY TEMPERATURE
CARBON 14 COMPOUNDS
RATS
ANIMALS
ANTIPYRETICS
AZOLES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRAZOLES
PYRAZOLINES
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques