The oncogenic action of ionizing radiation on rat skin

Technical Report · Tue Jan 01 04:00:00 EST 1991

DOI:https://doi.org/10.2172/5074858· OSTI ID:5074858

Burns, F J

Progress has occurred in several areas corresponding to the specific aims of the proposal: (1) Progression and multiple events in radiation carcinogenesis of rat skin as a function of LET; (2) cell cycle kinetics of irradiated rat epidermis as determined by double labeling and double emulsion autoradiography; (3) oncogene activation detected by in situ hybridization in radiation-induced rat skin tumors; (4) amplification of the c-myc oncogene in radiation-induced rat skin tumors as a function of LET; and (5) transformation of rat skin keratinocytes by ionizing radiation in combination with c-Ki-ras and c-myc oncogenes. 111 refs., 13 figs., 12 tabs.

• Research Organization: New York Univ., NY (United States). Dept. of Environmental Medicine
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60539
• OSTI ID: 5074858
• Report Number(s): DOE/ER/60539-10; ON: DE92002474
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARGON IONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CELL CYCLE
CELL TRANSFORMATIONS
CHARGED PARTICLES
DISEASES
DNA HYBRIDIZATION
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ELECTRON BEAMS
ENERGY TRANSFER
GENE AMPLIFICATION
GENE REGULATION
GENES
HAZARDS
HEALTH HAZARDS
HISTOLOGICAL TECHNIQUES
HYBRIDIZATION
ION BEAMS
IONIZING RADIATIONS
IONS
LEPTON BEAMS
LET
MAMMALS
NEON IONS
NEOPLASMS
ONCOGENES
ONCOGENIC TRANSFORMATIONS
ORGANS
PARTICLE BEAMS
PATHOGENESIS
PROGRESS REPORT
RADIATION EFFECTS
RADIATION HAZARDS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SKIN
VERTEBRATES