Germ cell comparative Drosophila mutagenesis: sensitivity and mutation pattern in chemically treated stem cells
Journal Article
·
· Environ. Manage.; (United States)
Mutagenesis studies on Drosophila oogonial cells with methylnitrosourea, dimethylnitrosamine, and diethylnitrosamine revealed unexpectedly high rates of sex-linked recessive lethals relative to other male and female germ cell stages. Indeed, the oogonial mutation rates with chemicals are higher than with massive x-ray or neutron exposures of oogonia. Analysis of the distribution of lethals per treated female suggests most of the mutations recovered are of independent origin, with very small levels of clustering of identical mutations. In the male stem cell population (spermatogonia) on the other hand, the distribution of lethals is primarily nonrandom and highly clustered. The nature of the mutational endpoint and the different pattern of germ cell development in the two sexes are the probable causes of this difference. The oogonial sensitivity to chemical mutagens may have important bearing on strategies for assessing human hazard.
- Research Organization:
- Univ. of Wisconsin, Madison
- OSTI ID:
- 5073705
- Journal Information:
- Environ. Manage.; (United States), Journal Name: Environ. Manage.; (United States) Vol. 5:6; ISSN EMNGD
- Country of Publication:
- United States
- Language:
- English
Similar Records
THE INFLUENCE OF RADIATION IN ALTERING THE INCIDENCE OF MUTATIONS IN DROSOPHILA . Progress Report on the Past Twelve Months and Renewal Proposal for the Period September 15, 1961 to September 14, 1962
Comparison of rates of sex-linked recessive lethals induced by ethylnitrosourea (ENU) in postmeiotic cells of the male and oogonia of the female Drosophila
THE ACTION OF RADIATION AND OTHER MUTAGENIC AGENTS (1) IN INDUCING MUTATION IN DROSOPHILA FEMALES, AND (2) IN CONTROLLING THE ACTION OF SPECIFIC GENES RESPONSIBLE FOR SUPPRESSING UNCONTROLLED GROWTH. Report Covering 9-Year Period, May 1, 1953-April 30, 1962
Technical Report
·
Wed May 31 00:00:00 EDT 1961
·
OSTI ID:4058562
Comparison of rates of sex-linked recessive lethals induced by ethylnitrosourea (ENU) in postmeiotic cells of the male and oogonia of the female Drosophila
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· Environ. Mutagen.; (United States)
·
OSTI ID:6410396
THE ACTION OF RADIATION AND OTHER MUTAGENIC AGENTS (1) IN INDUCING MUTATION IN DROSOPHILA FEMALES, AND (2) IN CONTROLLING THE ACTION OF SPECIFIC GENES RESPONSIBLE FOR SUPPRESSING UNCONTROLLED GROWTH. Report Covering 9-Year Period, May 1, 1953-April 30, 1962
Technical Report
·
Wed Jan 31 23:00:00 EST 1962
·
OSTI ID:4803545
Related Subjects
550400 -- Genetics
560154 -- Radiation Effects on Animals-- Basic Studies-- (-1987)
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
ARTHROPODS
BARYONS
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
DATA
DIPTERA
DROSOPHILA
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FERMIONS
FLIES
FRUIT FLIES
GAMETES
GENETIC EFFECTS
GERM CELLS
HADRONS
INFORMATION
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
LETHAL MUTATIONS
METHYL NITROSOUREA
MUTAGENESIS
MUTAGENS
MUTATIONS
NEUTRONS
NITROSAMINES
NITROSO COMPOUNDS
NUCLEONS
NUMERICAL DATA
OOGONIA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
SPERMATOGONIA
X RADIATION
560154 -- Radiation Effects on Animals-- Basic Studies-- (-1987)
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
ARTHROPODS
BARYONS
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
DATA
DIPTERA
DROSOPHILA
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FERMIONS
FLIES
FRUIT FLIES
GAMETES
GENETIC EFFECTS
GERM CELLS
HADRONS
INFORMATION
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
LETHAL MUTATIONS
METHYL NITROSOUREA
MUTAGENESIS
MUTAGENS
MUTATIONS
NEUTRONS
NITROSAMINES
NITROSO COMPOUNDS
NUCLEONS
NUMERICAL DATA
OOGONIA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
SPERMATOGONIA
X RADIATION