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Improved cognition after control of risk factors for multi-infarct dementia

Journal Article · · JAMA, J. Am. Med. Assoc.; (United States)
; ; ; ;
A cohort of 52 patients (30 men and 22 women) with multi-infarct dementia (MID) has been followed up prospectively for a mean interval of 22.2 months. Clinical course has been documented by serial history taking and interviews and neurological, medical, and psychological examinations, and correlated with measurements of cerebral blood flow. The clinical course and cognitive performance have been compared with those of age-matched normal volunteers and patients with Alzheimer's disease. Patients with MID were subdivided into hypertensive and normotensive groups, and also into those displaying stabilized or improved cognition and those whose condition deteriorated. Among hypertensive patients with MID, improved cognition and clinical course correlated with control of systolic blood pressure within upper limits of normalf (135 to 150 mm Hg), but if systolic blood pressure was reduced below this level, patients with MID deteriorated. Among normotensive patients with MID, improved cognition was associated with cessation of smoking cigarettes.
Research Organization:
Veterans Administration Medical Center, Houston, TX
OSTI ID:
5073132
Journal Information:
JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 256:16; ISSN JAMAA
Country of Publication:
United States
Language:
English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
AGED ADULTS
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
ELDERLY PEOPLE
HUMAN POPULATIONS
MINORITY GROUPS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANS
PATIENTS
POPULATIONS
RADIOISOTOPE SCANNING
TOMOGRAPHY
VASCULAR DISEASES