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Immunologic effects of whole body ultraviolet (uv) irradiation. II. Defect in splenic adherent cell antigen presentation for stimulation of T cell proliferation. [Mice]

Journal Article · · J. Immunol.; (United States)
OSTI ID:5072166
Ultraviolet (uv) irradiation has been shown to alter many parameters of the immunologic reactivity of mice. The altered responsiveness of uv-irradiated mice, as measured by delayed-type hypersensitivity (DTH) and primary in vitro plaque-forming cell (PFC) responses to T-dependent antigens, has recently been correlated with a functional defect in the splenic adherent cell population of these animals. The present studies describe a model of this altered responsiveness, which allows further clarification of the effects of external uv irradiation on the splenic antigen-presenting cell (APC) in its interactions with T cells.
Research Organization:
Harvard Medical School, Boston, MA
OSTI ID:
5072166
Journal Information:
J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 125:3; ISSN JOIMA
Country of Publication:
United States
Language:
English