Cholera toxin, a potent inducer of epidermal hyperplasia but with no tumor promoting activity in mouse skin carcinogenesis
Intracutaneous injection of cholera toxin into mice induced epidermal hyperplasia to a greater extent than 12-O-tetra-decanoylphorbol-13-acetate. It also induced adenylate cyclase and through weakly, ornithine decarboxylase of the epidermis. Cholera toxin, however, showed no tumor promoting activity in mouse skin carcinogenesis. In the single stage promotion, cholera toxin (50 ng) was injected once a week for 10 weeks into the skin of SENCAR mice initiated with 25 ..mu..g 7,12-dimethyl-benz(a)anthracene, but no tumors developed. In the two-stage promotion test, cholera toxin (10-100 ng) was injected for one or two weeks into the initiated skin and then mezerein (4 ..mu..g) was applied twice a week for 18 weeks, but the toxin did not increase incidence or numbers of papillomas.
- Research Organization:
- Univ. of Tokyo, Japan
- OSTI ID:
- 5071116
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Vol. 137:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Studies on the mechanisms of action of modifiers of skin carcinogenesis
Differential carcinogenic effects of intraperitoneal initiation with 7,12-dimethylbenz(a)anthracene or urethane and topical promotion with 12-O-tetradecanoylphorbol-13-acetate in skin and internal tissues of female SENCAR and BALB/c mice
Related Subjects
CYCLASES
ENZYME INDUCTION
DECARBOXYLASES
EPIDERMIS
CELL PROLIFERATION
PHORBOL ESTERS
TOXICITY
TOXINS
ADENYLIC ACID
CARCINOGENESIS
CHOLERA
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
INJECTION
MICE
ORNITHINE
TUMOR PROMOTERS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BACTERIAL DISEASES
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACIDS
CARCINOGENS
DATA
DISEASES
ENZYMES
EPITHELIUM
ESTERS
GENE REGULATION
INFECTIOUS DISEASES
INFORMATION
INTAKE
LYASES
MAMMALS
MATERIALS
NUCLEOTIDES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RODENTS
SKIN
TISSUES
TOXIC MATERIALS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)