Single lead acetate insult, testosterone therapy, and erythropoiesis in mice

Journal Article · Sat Oct 01 00:00:00 EDT 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529590· OSTI ID:5069531

Hogan, G R

Lead acetate (PbAc) was tested for its effects on the production and release of erythrocytes--that is, erythropoiesis-- in ICR mice. Dose-survival data indicate that a dosage of 20 mg PbAc/100 g body weight represents the maximum tolerable treatment level. No differences in survival at the various levels of the salt were observed with regard to sex or age. For erythropoietic effects of PbAc, mice were injected on day 0, and radioiron (/sup 59/Fe) incorporation percentages were determined at daily intervals through day 8 for both erythrocytes and splenic tissue. Control mice received isotonic saline as the injectate. On day 3, the percentages obtained from PbAc-treated mice showed a decline, reaching their minimum value by day 4. Recovery from erythropoietic suppression appeared to be complete by day 6 or 7; no positive overshoots in /sup 59/Fe percentages were found following recovery. These trends were typical for both peripheral red blood cells and spleen. Testosterone was administered to mice receiving saline or PbAc on two consecutive days (days -1 and 0). Radioiron uptake percentages for females receiving testosterone and saline showed an abrupt increase on day 4. No accelerative effect due to testosterone was found in recipient males. For females treated with testosterone and PbAc, the radioiron percentages for erythrocytes and spleen paralleled those for females receiving saline only. Male mice treated with both androgen and PbAc demonstrated /sup 59/Fe percentages typical of males treated with PbAc alone.

• Research Organization: Univ. of North Carolina, Charlotte
• OSTI ID: 5069531
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 3:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
LEAD COMPOUNDS
BIOLOGICAL EFFECTS
ANDROGENS
BIOLOGICAL ACCUMULATION
BLOOD CELLS
DOSE-RESPONSE RELATIONSHIPS
ERYTHROCYTES
ERYTHROPOIESIS
IRON 59
MICE
SEX DEPENDENCE
SPLEEN
TESTOSTERONE
THERAPY
ANDROSTANES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD FORMATION
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPES
KETONES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551000 - Physiological Systems