Effect of pulmonary irradiation from inhaled /sup 90/Y on immunity to Listeria monocytogenes in mice

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Tex. Rep. Biol. Med.; (United States)

OSTI ID:5061782

Sanchez, A; Lundgren, D L; McClellan, R O

The immunological response of mice subjected to irradiation from particles deposited in the lungs and challenged with Listeria monocytogenes was investigated. Mice, exposed by inhalation to /sup 90/Y (a beta-emitting radionuclide) in relatively insoluble fused aluminosilicate particles, were immunized with L. monocytogenes either before or after exposure. Two additional groups of mice were either immunized or irradiated only. A group of control mice received no irradiation or immunization. The beta radiation dose absorbed by the lungs of each mouse at time of challenge averaged 10,000 rads. Fourteen days after immunization, all mice were challenged with 2 LD/sub 50/ doses of L. monocytogenes via the respiratory route. Survival of all immunized mice either with or without exposure to /sup 90/Y varied from 90 to 100% as compared to 10 to 20% for the mice irradiated only and for control mice through 14 days after challenge. Pulmonary clearance of inhaled L. monocytogenes during the first 4 hr after challenge was suppressed in the mice irradiated only but not in those immunized only, or in the immunized and irradiated groups, and control mice. There appeared to be a suppression of proliferation of L. monocytogenes in lungs and spleen in the immunized groups 72 hr after challenge, whereas the lungs and spleens of the mice irradiated only and the control mice had extensive bacterial invasion. It was concluded that the 10,000 rads of beta radiation absorbed by the lungs did not suppress the immune mechanisms of the immunized mice.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• OSTI ID: 5061782
• Journal Information: Tex. Rep. Biol. Med.; (United States), Journal Name: Tex. Rep. Biol. Med.; (United States) Vol. 34:2-4; ISSN TRBMA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BETA PARTICLES
BIOLOGICAL EFFECTS
BODY
CHARGED PARTICLES
DOSE-RESPONSE RELATIONSHIPS
IMMUNE REACTIONS
IMMUNITY
INHALATION
INTAKE
IRRADIATION
ISOTOPES
LUNGS
MAMMALS
MICE
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES