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Primary structure of keratinocyte transglutaminase

Journal Article · · Proceedings of the National Academy of Sciences of the United States of America; (United States)
; ; ;  [1];  [2]; ;  [3]
  1. Univ. of California, Davis (United States)
  2. Univ. of Cincinnati Medical Center, OH (United States)
  3. National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States)
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The nucleotide and deduced amino acid sequences of the coding regions of human and rat keratinocyte transglutaminases (protein-glutamine: amine {gamma}-glutamyltransferase; EC 2.3.2.13) have been determined. These yield proteins of {approximately}90 kDa that are 92% identical, indicative of the conservation of important structural features. Alignments of amino acid sequences show substantial similarity among the keratinocyte transglutaminase, human clotting factor XIII catalytic subunit, guinea pig liver tissue transglutaminase, and the human erythrocyte band-4.2 protein. The keratinocyte enzyme is most similar to factor XIII, whereas the band-4.2 protein is most similar to the tissue transglutaminase. A salient feature of the keratinocyte transglutaminase is its 105-residue extension beyond the N terminus of the tissue transglutaminase. This extension and the unreltaed activation peptide of factor XIII (a 37-residue extension) appear to be added for specialized functions after divergence of the tissue transglutaminase from their common lineage.

OSTI ID:
5044523
Journal Information:
Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 87:23; ISSN 0027-8424; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY
BODY FLUIDS
COAGULANTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DNA
DNA SEQUENCING
DRUGS
ENZYMES
EPIDERMIS
EPITHELIUM
ERYTHROCYTES
GLANDS
HEMATOLOGIC AGENTS
ISOTOPES
LIGHT NUCLEI
LIVER
MAMMALS
MAN
MATERIALS
MOLECULAR STRUCTURE
NITROGEN TRANSFERASES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
PROTEINS
RADIOISOTOPES
RATS
RECOMBINANT DNA
RODENTS
SKIN
STRUCTURAL CHEMICAL ANALYSIS
TISSUES
TRANSFERASES
VERTEBRATES