Preliminary toxicological study of kerimide 601 resin

Technical Report · Tue Feb 28 23:00:00 EST 1978

DOI:https://doi.org/10.2172/5042473· OSTI ID:5042473

Smith, D M; Drake, G A; London, J E; Wilson, J S; Holland, L M; Thomas, R G

The acute oral LD/sub 50/ values for kerimide 601 resin for mice and rats is greater than 5 g/kg. According to classical guidelines, the mixture would be considered slightly or practically nontoxic in both species. Skin application studies in the rabbit with kerimide 601 resin demonstrated that it was cutaneously nonirritating. This resin was also nonirritating in rabbit eye application studies. The sensitization study in the guinea pig did not show resin to be deleterious in this regard, although delayed necrosis was seen at the injection sites 96 h after administration.

• Research Organization: Los Alamos Scientific Lab., N.Mex. (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 5042473
• Report Number(s): LA-7207-MS
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
EYES
GUINEA PIGS
HAZARDOUS MATERIALS
INGESTION
INTAKE
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PETROCHEMICALS
PETROLEUM PRODUCTS
POLYMERS
RATS
RESINS
RODENTS
SENSE ORGANS
SENSITIVITY
SKIN
TESTING
TOXICITY
VERTEBRATES