Myocardial perfusion with rubidium-82. II. Effects of metaolic and pharmacologic interventions. [Dogs]
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5028540
In order to validate a new method for quantifying coronary blood flow, a bolus of rubidium-82 (Rb-82) was injected intravenously into 28 open-chested dogs under a wide range of flow and physiologic conditions, using beta probes to monitor myocardial radioactivity. Extraction fraction and perfusion were measured using a functional model that separates the data into the free and trapped myocardial rubidium. Extraction and uptake of rubidium were lower during acidosis than during alkalosis and were unchanged by glucose-insulin, digoxin, or propranolol. Myocardial flow, as indicated by rubidium, correlated linearly with simultaneous measurements of flow by microspheres in the same sample volume over a wide range of flow (r = 0.97, n = 106, range 0.02 to 7.75 ml/min/g). Regional myocardial blood flow can be accurately determined using generator-produced Rb-82. Studies using current state-of-the-art, fast positron-emission tomographic cameras are required to determine the utility of this approach in man.
- Research Organization:
- Univ. of Texas Medical School; Graduate School of Biomedical Sciences, Houston; Los Alamos National Lab., NM
- OSTI ID:
- 5028540
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:10; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model
Rubidium-82 myocardial uptake and extraction after transient ischemia: PET characteristics
Skeletal muscle blood flow in vivo: detection with rubidium-82 and effects of glucose, insulin, and exercise
Journal Article
·
Mon Oct 01 00:00:00 EDT 1990
· Circulation; (USA)
·
OSTI ID:6369005
Rubidium-82 myocardial uptake and extraction after transient ischemia: PET characteristics
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· J. Comput. Assist. Tomogr.; (United States)
·
OSTI ID:6702616
Skeletal muscle blood flow in vivo: detection with rubidium-82 and effects of glucose, insulin, and exercise
Journal Article
·
Wed Jul 01 00:00:00 EDT 1987
· J. Nucl. Med.; (United States)
·
OSTI ID:6215660
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PERFUSED TISSUES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
TISSUES
TOMOGRAPHY
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PERFUSED TISSUES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
TISSUES
TOMOGRAPHY
VERTEBRATES